2 edition of Poly-[alpha]-amino acids; protein models for conformational studies. found in the catalog.
Poly-[alpha]-amino acids; protein models for conformational studies.
Gerald D. Fasman
|Statement||Edited by Gerald D. Fasman.|
|Series||Biological macromolecules ;, v. 1|
|LC Classifications||QP801.A5 F3|
|The Physical Object|
|Pagination||xv, 764 p.|
|Number of Pages||764|
|LC Control Number||66027704|
Recent studies have identified conformational variants of α-syn strains that exhibit distinct neurotoxicity, seeding abilities, and propagation, which contribute to different properties of α-synucleinopathies (24, 25). Given that α-syn PFF induces PARP activation and PAR accumulation, PAR then accelerates α-syn fibrillization and changes Cited by: Klingstedt, T. & Nilsson, K. P. Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates. Biochem. by: 3.
This email contains the top scoring 3D model of the user's protein and a link to a web page containing a wide range of predicted structural features, including secondary structure, disorder, potential binding sites, SCOP fold and superfamily annotations, and 3D models with confidence estimates for the top 10 matching potential homologous. This review describes (from both the animal and human literature) the biological consequences of losses in nervous system docosahexaenoate (DHA). It then concentrates on biological mechanisms that may serve to explain changes in brain and retinal function. Brief consideration is given to actions of DHA as a nonesterified fatty acid and as a docosanoid or other bioactive by:
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from these microbes have breached physical barriers such as the skin or intestinal tract mucosa Membranome: 7. The results of such studies provide important constraints on theories, which typically predict the full three-dimensional distribution of the screening cloud. This article reviews the state of nucleic acid ion counting measurements and critically analyzes their ability to test both analytical and simulation-based by:
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Abstract. Poly 8-bromoadenylic acid [poly(BBrA)] is the only known all-syn polynucleotide. It shows a helix-coil transition with a melting curve centred around 55 degrees C. Energy calculations based on classical potential functions have been used to explore the three-dimensional structure of this polymer in helix and random by: The unfolded state and flexible linkers in the folded structure play essential roles in protein stability and folding and protein−protein interactions.
Intrinsic to these roles is the fact that unfolded proteins and flexible linkers sample many different conformations.
Polymer models may capture this and complement experiments in elucidating the contributions of the unfolded state and Cited by: Poly 8-bromoadenylic acid [poly(BBrA)] is the only known all-syn polynucleotide. It shows a helix-coil transition with a melting curve centred around 55 degrees C. Energy calculations based on classical potential functions have been used to explore the three-dimensional structure of.
Influenza polymerase employs unique mechanisms to synthesize 5′ capped and 3′ poly-adenylated viral mRNA. Capped oligomers of 10–15 nt long, pirated from nascent Pol II transcripts, are used to prime transcription (Lukarska et al.,Plotch et al., ). Structure of poly 8-bromoadenylic acid; conformational studies by CPF energy calculations.
Nucleic Acids Res. Aug; 4 (8)– [PMC free article] Hingerty B, Broyde S. A model for the single stranded random coil form of polydeoxyadenylic acid from minimum energy conformations of Cited by: Studies by synchrotron X-ray scattering, and circular dichroism, absorption and fluorescence spectroscopy.
J Mol Biol. Jan 9; (1)– Balbach J, Forge V, van Nuland NA, Winder SL, Hore PJ, Dobson CM. Following protein folding in real time using NMR spectroscopy. Nat Struct Biol. Oct; 2 (10)–Cited by: Polymerization of PLA has been conducted since by either a Direct Poly-Condensation of lactic acid, or by a Ring-Opening reaction of lactide, a cyclic dimer of lactic acid.
Both methods rely on highly purified polymer-grade lactic acid or lactide to produce PLA Author: K. Jim Jem, K. Jim Jem, Bowen Tan. Model building studies  have, in fact, shown the possibility of such arrangements with poly-a-deoxynucleotide strands, and that these a-strands can form helical, base-paired and stacked complexes with either a complementary strand or a-strand (although in the latter case the 3' end of one and the 5' end of the other must be `up', so that Cited by: Poly(I): poly(C)–agarose [ml suspension containing 6 mg of poly(I): poly(C)] is washed twice by centrifuging at g for 5 min at 4°, discarding the supernatant, and resuspending in 50 ml of buffer B [10 mM HEPES (pH ), 50 mM KCl, mM magnesium acetate, 7 mM 2-mercaptoethanol, and 20% (v/v) glycerol].
The final pellet of poly(I. Here, we show the first, preliminary model of a channel membrane protein that is functionally incorporated in a completely artificial polymer, Cited by: Atkins ED, Nieduszynski IA, Mackie W, Parker KD, Smolko EE (b) Structural components of alginic acid.
The crystalline structure of poly-alpha-L-guluronic acid. Results of x-ray diffraction and polarized infrared studies. Biopolymers – Google ScholarCited by: In the case of murine hepatitis virus, the receptor is a member of the immunoglobulin superfamily, carcinoembryonic antigen-related cellular adhesion molecule (CEACAM), and antibodies against this protein block virus attachment.
Many alpha coronaviruses utilize aminopeptidase N (APN) as their receptor. Entry into the cell. The TSP1 domain forms part of the oligomer interface.
Structural studies on other MACPF/CDC proteins reveal that most interactions within the prepore or pore assembly appear to be formed between the relatively flat faces of the MACPF domain 8,11,In contrast the poly-C9 structure reveals that the TSP1 domain packs against the C-terminal α-helix of the MACPF domain of an Cited by: Kinetic studies of the helix-coil transition in aqueous solutions of poly(L-lysine).
Biopolymers18 (3), DOI: /bip Bernhard Bösterling, Jürgen Engel. Kinetic studies on the helix-coil transition of fluorescent labeled poly(-L-lysine) by the temperature-jump by: Lipids are the main component of cellular membranes. They are highly diverse in structure, and the distribution of different lipids and their species (membrane lipid Cited by: Pathogenesis in protein conformational diseases is initiated by changes in protein secondary structure.
This molecular restructuring presents an opportunity for novel shape-based detection approaches, as protein molecular weight and chemistry are otherwise unaltered. Here we apply molecular imprinting to discriminate between distinct conformations of the model protein β-lactoglobulin (BLG).Cited by: The Calmodulin-Binding Domain of Caldesmon Binds to Calmodulin in -Helical Conformation.
Biochemistry33 (5), DOI: /bia Allostery and protein substrate conformational change during GroEL/GroES-mediated protein folding.
Model Peptide Studies Demonstrate That Amphipathic Secondary Cited by: Carroll D. Optical properties of deoxyribonucleic acid--polylysine complexes. Biochemistry. Feb 1; 11 (3)– Chang C, Weiskopf M, Li HJ. Conformational studies of nucleoprotein. Circular dichroism of deoxyribonucleic acid base pairs bound by polylysine.
Biochemistry. Jul Cited by: 9. Nucleic Acid Research: Future Development reflects the exchange of ideas and information among the participants of ""The Future of Nucleic Acid Research"" symposium held at Kyoto on December This publication aims to extend the ideas presented in the symposium and to provide facts that can answer various scientific questions, particularly.
Gorrasi G., Pantani R. () Hydrolysis and Biodegradation of Poly(lactic acid). In: Di Lorenzo M., Androsch R. (eds) Synthesis, Structure and Properties of Poly(lactic acid).
Advances in Polymer Science, vol Cited by:. As a new family of soft materials, peptide/protein–polymer conjugates can lead to a wide range of potential biological and nonbiological applications. The performance of these materials depends on the protein structure and phase behavior arising from a balance between the enthalpic interactions of the components and surrounding media as well as the entropic contribution associated with Cited by: The membrane attack complex (MAC)/perforin-like protein complement component 9 (C9) is the major component of the MAC, a multi-protein complex that forms pores in the membrane of target by: Web 3DNA (w3DNA) is a significantly enhanced version of the widely used w3DNA server for the analysis, visualization, and modeling of 3D nucleic-acid-containing structures.
Since its initial release inthe w3DNA server has continuously served the community by making commonly-used features of the 3DNA suite of command-line programs Cited by: 5.